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KMID : 0620920150470030002
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Experimental & Molecular Medicine
2015 Volume.47 No. 3 p.2 ~ p.2
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The role of mitochondrial DNA mutation on neurodegenerative diseases
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Cha Moon-Yong
Kim Dong-Kyu
Mook-Jung Inhee
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Abstract
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Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
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